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THC induced hyperemesis syndrome



Watch these 2 videos from Dr. Mellick’s Channel: http://www.youtube.com/watch?v=fzL84KrPMjs
and http://youtu.be/w-02YgBbiDU

Cannabis is one of the most commonly abused drugs worldwide. Over the past decade, marijuana has remained the most commonly used illicit substance with close to 50% of high school seniors admitting use at some time[1]. It is estimated that each year 2.6 million individuals in the USA become new users and most are younger than 19 years of age.

The long-term and short-term toxicity of cannabis abuse is associated with pathological and behavioural effects. However, cannabis has also been suggested to have therapeutic properties with anticonvulsive, analgesic, antianxiety and anti-emetic activities. Cannabis has also been used to treat anorexia in patients with acquired immunodeficiency syndrome[3–5]. The actions of cannabis are mediated by specific cannabinoid receptors. The first of the cannabinoid receptors-CB-1-was identified in 1990 and this finding revolutionized the study of cannabinoid biology. Since then, a multitude of roles for the endogenous cannabinoid system has been proposed. A large number of endogenous cannabinoid neurotransmitters or endocannabinoids have been identified, and the CB-1 and CB-2 cannabinoid receptors have been characterized[7]. The CB-1 receptors exert a neuromodulatory role in the central nervous system and enteric plexus[8]. Cannabinoid type 2 receptors have an immunomodulatory effect and are located on tissues such as microglia[5]. The presence of other receptors, transporters, and enzymes responsible for the synthesis or metabolism of endocannabinoids are being recognised at an extraordinary pace. Cannabinoids have a wide variety of effects on the body systems and physiologic states due to their actions on the receptors as well as direct toxic effects.

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