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Scientists HIJACKED yeast to make CANNABINOIDS!!!



Can cannibinoids only be created by marijuana? Are there more cost effective ways to produce pure cannibinoids? Find the answers in this review of: Complete biosynthesis of cannabinoids and their unnatural analogues in yeast. Luo X, Reiter MA, d’Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, Lee H, Yu C, Shin J, Deng K, Benites VT, Wang G, Baidoo EEK, Chen Y, Dev I, Petzold CJ, Keasling JD. Nature. 2019 Mar;567(7746):123-126. doi: 10.1038/s41586-019-0978-9..

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Scientists genetically modified brewers’ yeast to make the yeast produce cannabinoids, including cannabinoids that have never been seen! We look at how this was achieved and how this could change the face of cannabinoid research and medicinal science as a whole!

Creator: Natasha Leiloo

References:
Apel, A. R., D’Espaux, L., Wehrs, M., Sachs, D., Li, R. A., Tong, G. J., Garber, M., Nnadi, O., Zhuang, W., Hillson, N. J., Keasling, J. D., & Mukhopadhyay, A. 2017. A Cas9-based toolkit to program gene expression in Saccharomyces cerevisiae. Nucleic Acids Research 45: 496–508.
Luo, X., Reiter, M. A., d’Espaux, L., Wong, J., Denby, C. M., Lechner, A., Zhang, Y., Grzybowski, A. T., Harth, S., Lin, W., Lee, H., Yu, C., Shin, J., Deng, K., Benites, V. T., Wang, G., Baidoo, E. E. K., Chen, Y., Dev, I., … Keasling, J. D. 2019. Complete biosynthesis of cannabinoids and their unnatural analogues in yeast. Nature 567: 123–126.
Trantas, E., Panopoulos, N., & Ververidis, F. 2009. Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae. Metabolic Engineering 11: 355–366.
Wang, T., Ma, X., Zhu, H., Li, A., Du, G., & Chen, J. (2012). Available methods for assembling expression cassettes for synthetic biology. Applied Microbiology and Biotechnology 93: 1853–1863.
Wu, T., Li, S., Zhang, B., Bi, C., & Zhang, X. 2018. Engineering Saccharomyces cerevisiae for the production of the valuable monoterpene ester geranyl acetate. Microbial Cell Factories 17: 85–85.
Zirpel, B., Degenhardt, F., Martin, C., Kayser, O., & Stehle, F. 2017. Engineering yeasts as platform organisms for cannabinoid biosynthesis. Journal of Biotechnology 259: 204–212.

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